TL;DR
Emotional storytelling helps research audiences remember a finding and follow it, and meta-analyses show that narratives shift beliefs and intentions by small but real amounts. The popular oxytocin explanation is far less settled than it sounds. A single vivid case can also crowd out the numbers, so we pair stories with data and size the emotion to the finding.
Updated October 14, 2026. First published July 2018.
In 2018 we wrote this post for B2B marketers. It called emotional storytelling a superpower, walked through Joseph Campbell’s hero’s journey, and urged brands to make their buyers feel something. Most of that still works for selling software. It says little to a cardiologist planning a patient video, or to a research team trying to get a finding in front of a ministry.
Our work has moved toward research, healthcare and government, so we went back to the evidence with a narrower question. What does emotion do to understanding, and when can a research audience trust a story that moves them? Some of what gets repeated about emotional storytelling holds up. Some of it, including the most quoted neuroscience, is shakier than the conference slides suggest.
What does emotional storytelling do in the brain?

Emotion changes what the brain keeps. In a 2004 review, the neurobiologist James McGaugh drew together animal and human research showing that emotionally arousing experiences activate the amygdala, which in turn strengthens how memories are consolidated in other brain regions (McGaugh, 2004).
A story adds a second effect. A Princeton team used fMRI to record a speaker telling a real-life story, then recorded listeners hearing it.
The listeners’ brain activity tracked the speaker’s in space and time, and the coupling vanished when communication failed. Listeners whose activity ran slightly ahead of the speaker’s, anticipating what came next, understood the story best (Stephens, Silbert & Hasson, 2010).
Neither study shows that emotion makes anyone agree. They point to two advantages, in memory and in comprehension, that a dense research topic rarely gets on its own. Our post on emotional decision-making covers what feeling does further along.
Does the oxytocin explanation of emotional storytelling hold up?

The most quoted explanation involves oxytocin. Paul Zak’s lab reported that character-driven stories change viewers’ physiology in ways that predict later donations (Zak, 2015), and that a nasal dose of oxytocin increased the influence of public service advertisements (Lin et al., 2013). The “trust molecule” idea spread fast from there.
It has aged poorly.
A critical review found that the simplest result, intranasal oxytocin raising trust, has not replicated well, and that the way oxytocin is measured in blood and other bodily fluids is flawed. The authors concluded that the accumulated research does not convincingly tie human trust to oxytocin (Nave, Camerer & McCullough, 2015).
A more careful bedside study exists. In a randomised trial with 81 children in hospital intensive care units, one 30-minute storytelling session raised salivary oxytocin, lowered cortisol and reduced reported pain compared with a riddle game (Brockington et al., 2021). Its oxytocin readings come from saliva, the kind of peripheral measure Nave and colleagues questioned.
We find it encouraging, though one trial of same-day effects cannot support a promise that a video will change anyone’s hormones.
How much can narrative transportation change what people believe?

Psychologists Melanie Green and Timothy Brock put the experience of being lost in a story to the test in 2000. They defined transportation as absorption into a story. Across four experiments with 97, 69, 274 and 258 participants, more transported readers held more story-consistent beliefs and rated the protagonists more favourably.
Highly transported readers also spotted fewer “false notes” in the story. Labelling the story as fact or as fiction left transportation and the matching beliefs largely unchanged (Green & Brock, 2000).
For science communicators that cuts both ways. A transported reader gives an accurate story less needless resistance, and gives an inaccurate one less scrutiny.
How large is the effect? Kurt Braddock and James Dillard pooled studies comparing narratives with non-narrative messages.
Exposure to a narrative was associated with narrative-consistent beliefs (r = .17; k = 37, N = 7,376), attitudes (r = .19; k = 40, N = 7,132) and intentions (r = .17; k = 28, N = 5,211).
The estimate for behaviours was r = .23, from just five studies and 978 people. The medium of presentation did not change the size of the effect, which is useful to know when choosing between a written case and a video (Braddock & Dillard, 2016).
By the usual conventions those are small effects, and the authors found signs of moderators they could not identify. Stories move people a little, on average. Anyone promising that a single story will transform an audience is reading past the meta-analysis.
Chen, Dong and Wang pooled 19 articles on character similarity. A character resembling the audience produced stronger identification (d = 0.14) and self-referencing (d = 0.16), while the effect on transportation itself was only marginally significant.
Similarity on chosen traits such as occupation and place of residence mattered more than similarity in age or sex (Chen, Dong & Wang, 2024).
Our 2018 post told marketers to make the customer the hero and the brand the guide. The similarity research gives that advice a research form.
The hero is usually the patient or community living with the finding, ideally someone who shares the audience’s work or neighbourhood, and the research team plays the guide. For the wider research on persuasive communication, we keep a separate summary.
What does narrative medicine add for clinicians?

Clinicians reached emotional storytelling from the other direction. In 2001 Rita Charon, a physician at Columbia, defined narrative competence as “the ability to acknowledge, absorb, interpret, and act on the stories and plights of others” (Charon, 2001).
The outcome evidence is early. A 2024 systematic review found 13 articles describing 12 narrative medicine interventions for oncology professionals, all reported by their authors as feasible and acceptable (Paul et al., 2024).
A review of randomised trials on practitioner empathy found that all 14 trials (80 practitioners, 1,986 patients) pointed toward higher patient satisfaction. Reporting was too thin to estimate an overall effect (Keshtkar et al., 2024).
Charon’s four verbs double as a brief for storytelling in healthcare video, which has to acknowledge a person’s experience before it can ask them to act.
When does an emotional story mislead?

Emotion can pull an audience away from the evidence as well as toward it. Deborah Small, George Loewenstein and Paul Slovic ran field experiments in which people paid for a short survey could give part of the money to Save the Children.
People shown a seven-year-old girl named Rokia gave an average of $2.12, against $1.21 for people shown statistics about food shortages. When participants were first taught about this gap, they gave less to Rokia and no more to the statistics (Small, Loewenstein & Slovic, 2007).
Every patient video meets a version of this. One vivid case sits beside a population figure, and attention goes to the case. A clinician watching may know the case is unusual; a patient watching has no way to tell.
Story and statistic also do different jobs. A meta-analysis comparing them found that statistical evidence had more influence on beliefs and attitudes, while narrative evidence had more influence on intention (Zebregs et al., 2015). The authors advised matching the type of evidence to the main communication objective.
Then there is emotion the research cannot support. A swelling score over a modest effect asks the audience to feel more than the data justify. A grant reviewer who finds a story where the methods should be will usually read it as a gap in the methods.
How do we build emotional storytelling that respects the evidence?

We start from the decision the audience has to make. If beliefs need to change, the numbers lead and the story gives them a face. If intention is the target, the story can lead. In our visual storytelling process, emotional connection comes in the second stage, once the key insights and audience context are settled.
A pilot study gets a curious, open tone. A decade of trial evidence can carry more weight. Calibrating feeling to finding is a large part of research and healthcare communication.
Frequently asked questions about emotional storytelling
If you would like to see how we have handled emotion in research and health projects, browse some of our recent work.
And if you have a finding that deserves a story, and you want that story to stay inside what the evidence supports, we would be glad to talk it through. For an occasional note when we publish something new, you can sign up here.
Sources
- Braddock, K., & Dillard, J. P. (2016). Meta-analytic evidence for the persuasive effect of narratives on beliefs, attitudes, intentions, and behaviors. Communication Monographs, 83(4), 446-467. doi.org/10.1080/03637751.2015.1128555
- Brockington, G., Gomes Moreira, A. P., Buso, M. S., Gomes da Silva, S., Altszyler, E., Fischer, R., & Moll, J. (2021). Storytelling increases oxytocin and positive emotions and decreases cortisol and pain in hospitalized children. PNAS, 118(22), e2018409118. www.pnas.org/doi/10.1073/pnas.2018409118
- Charon, R. (2001). Narrative medicine: A model for empathy, reflection, profession, and trust. JAMA, 286(15), 1897-1902. doi.org/10.1001/jama.286.15.1897
- Chen, M., Dong, Y., & Wang, J. (2024). A meta-analysis examining the role of character-recipient similarity in narrative persuasion. Communication Research, 51(1), 56-82. doi.org/10.1177/00936502231204834
- Green, M. C., & Brock, T. C. (2000). The role of transportation in the persuasiveness of public narratives. Journal of Personality and Social Psychology, 79(5), 701-721. doi.org/10.1037/0022-3514.79.5.701
- Keshtkar, L., Madigan, C. D., Ward, A., et al., & Howick, J. (2024). The effect of practitioner empathy on patient satisfaction: A systematic review of randomized trials. Annals of Internal Medicine, 177(2), 196-209. doi.org/10.7326/M23-2168
- Lin, P.-Y., Grewal, N. S., Morin, C., Johnson, W. D., & Zak, P. J. (2013). Oxytocin increases the influence of public service advertisements. PLoS ONE, 8(2), e56934. doi.org/10.1371/journal.pone.0056934
- McGaugh, J. L. (2004). The amygdala modulates the consolidation of memories of emotionally arousing experiences. Annual Review of Neuroscience, 27, 1-28. doi.org/10.1146/annurev.neuro.27.070203.144157
- Nave, G., Camerer, C., & McCullough, M. (2015). Does oxytocin increase trust in humans? A critical review of research. Perspectives on Psychological Science, 10(6), 772-789. doi.org/10.1177/1745691615600138
- Paul, T. K., Reddy, Y., Gnanakumar, A., et al., & Kaye, E. C. (2024). Narrative medicine interventions for oncology clinicians: A systematic review. Supportive Care in Cancer, 32, 241. doi.org/10.1007/s00520-024-08434-1
- Small, D. A., Loewenstein, G., & Slovic, P. (2007). Sympathy and callousness: The impact of deliberative thought on donations to identifiable and statistical victims. Organizational Behavior and Human Decision Processes, 102(2), 143-153. doi.org/10.1016/j.obhdp.2006.01.005
- Stephens, G. J., Silbert, L. J., & Hasson, U. (2010). Speaker-listener neural coupling underlies successful communication. PNAS, 107(32), 14425-14430. www.pnas.org/doi/10.1073/pnas.1008662107
- Zak, P. J. (2015). Why inspiring stories make us react: The neuroscience of narrative. Cerebrum, 2015, 2. pubmed.ncbi.nlm.nih.gov/26034526/
- Zebregs, S., van den Putte, B., Neijens, P., & de Graaf, A. (2015). The differential impact of statistical and narrative evidence on beliefs, attitude, and intention: A meta-analysis. Health Communication, 30(3), 282-289. doi.org/10.1080/10410236.2013.842528